HEALTH EFFECTS|Skin or Sense Organ Toxicity References

Skin or Sense Organ Toxicity References
There is no generally accepted source for an authoritative list of chemicals that are recognized to cause skin or sensory organ toxicity.

Environmental Defense's list of suspect skin or sensory organ toxicants is compiled from the following sources:

AEGL: US EPA, National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances. Notices. 62 Federal Register: 58839-58851 (October 30, 1997)

ATSDR: Agency for Toxic Substances and Disease Registry. Minimal risk Levels for Hazardous Substances. January 2004.

CARB-TAC: California Air Resources Board. Toxic Air Contaminant Fact Sheets.

EDF: See Environmental Defense's Custom Hazard Identification documentation.

EEC: European Economic Community. Sensitizing Substances in the EEC List of Dangerous Substances. Annex I to Council Directive 67/548/EEC.

EPA-HEN: US EPA, Air Risk Information Support Center. Health Effects Notebook for Hazardous Air Pollutants.

EPA-TRI: US EPA. Addition of Certain Chemicals; Toxic Chemical Release Reporting; Community Right to Know. Proposed and Final Rules. 59 Federal Register 1788 (Jan 12, 1994); 59 Federal Register 61432 (November 30, 1994). Summarized in Hazard Information on Toxic Chemicals Added to EPCRA Section 313 Under Chemical Expansion.

HARV: Harvell, J., M. Bason and H. Maibach. Contact Urticaria and its Mechanisms. Food Chemistry and Toxicology 32(2): 103-112. 1994. (Table 2: Substances identified as capable of causing contact urticaria).

HAZMAP: A Relational Database of Hazardous Chemicals and Occupational Diseases. Browse Haz-Map by Adverse Effects: Dermatotoxin.

KLAA: Klaassen, C., M. Amdur and J. Doull (eds.). Casarett and Doull's Toxicology. The Basic Science of Poisons, 5th Ed. Pergamon Press, NY. 1996. (Tables 18-2: Selected Chemicals Causing Skin Burns, Table 18-3: Common Contact Allergens, Table 18- 6: Selected Phototoxic Agents, Table 18-8: Causes of Chloracne).

LADO: LaDou, J. (ed.). Occupational Medicine. Appleton & Lange, Norwalk, CN. 1990. (Table 17-1: Occupational phototoxic dermatitis: Causes and workers affected, Table 17-4: Common causes of occupational allergic contact dermatitis and typical occupational groups affected, Table 17-5: Established causes of occupational vitiligo, Table 17-8: Occupational cutaneous carcinogens and occupations with significant exposure).

LOCK: Lock, E.A., and E. Harpur. Toxicology of Sensory System: A Perspective. Human and Experimental Toxicology. 11(6): 442-448. 1992. (Table 1: Chemicals that induce olfactory lesions in experimental animals by either inhalation and/or non-inhalation routes).

LU: Lu, F.C. Basic Toxicology. 2nd Edition. 1991. (Appendix 15-1: Cataractogenic Chemicals).

NJ-FS: New Jersey Department of Health Services. Right to Know Program, NJDOH, Trenton, NJ.

NTP-HS: National Toxicology Program. Chemical Repository of Health and Safety Data.[Insert CAS#].txt

OEHHA-AREL: California EPA, Office of Environmental Health Hazard Assessment. Acute Reference Exposure Levels (RELs), Averaging Times, and Toxicologic Endpoints. Includes all Acute Reference Exposure Levels (ARELs) developed by OEHHA through May 2000

OEHHA-CREL: California EPA, Office of Environmental Health Hazard Assessment. Air Toxics Hot Spots Program Risk Assessment Guidelines, Part III: Technical Support Document "Determination of Noncancer Chronic Reference Exposure Levels". Includes all Chronic Reference Exposure Levels (CRELs) adopted by OEHHA as of August 2003 (, plus draft CRELS proposed through March 2004 (

RTECS: National Institute for Occupational Safety and Health's Registry of Toxic Effects of Chemical Substances. See Environmental Defense's Suspect Hazard Identification documentation.

TIMB: Timbrell, J.A. Introduction to Toxicology. Taylor and Francis, New York. 1995. (Table 5.1: Types of skin sensitizers).