HEALTH EFFECTS|Neurotoxicity References

Neurotoxicity References
There is no generally accepted source for an authoritative list of chemicals that are recognized to cause neurotoxicity.

Environmental Defense's list of suspect neurotoxicants is compiled from the following sources:

AEGL: US EPA, National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances. Notices. 62 Federal Register: 58839-58851 (October 30, 1997)

ATSDR: Agency for Toxic Substances and Disease Registry. Minimal risk Levels for Hazardous Substances. January 2004.

CAA-AQC: US EPA, Office of Research and Development. Air Quality Criteria for Carbon Monoxide. Washington, DC, December 1991.

CARB-TAC: California Air Resources Board. Toxic Air Contaminant Fact Sheets.

DAN: Nordic Council of Ministers and Danish National Institute of Occupational Health. Neurotoxic Substances in the Working Environment (Danish ad hoc list). List originally published in Neurotoxic Substances in the Work Environment, Danish Working Environment Service, At-report Nr. 13/1990.

DPR-CIP: California EPA, Department of Pesticide Regulation. Summary of Pesticide Use Report Data 2001 Indexed by Chemical: Use Trends of Cholinesterase Inhibiting Pesticides.

EDF: See Environmental Defense's Custom Hazard Identification documentation.

EPA-HEN: US EPA, Air Risk Information Support Center. Health Effects Notebook for Hazardous Air Pollutants.

EPA-SARA: US EPA. Roadmaps to Sources of Information on Chemicals Listed in the Emergency Planning Community and Community Right-to-Know Act (Also Known as SARA Title 3), Section 313 Toxic Release Inventory (for Microcomputers). (Report Number EPADFDK92040). 1991. Data file distributed in 2 diskettes by Office of Pollution, Prevention, and Toxics, Environmental Protection Agency, Washington, DC. NOTE: Datasource no longer being maintained by EPA; not currently available online.

EPA-TRI: US EPA. Addition of Certain Chemicals; Toxic Chemical Release Reporting; Community Right to Know. Proposed and Final Rules. 59 Federal Register 1788 (Jan 12, 1994); 59 Federal Register 61432 (November 30, 1994). Summarized in Hazard Information on Toxic Chemicals Added to EPCRA Section 313 Under Chemical Expansion.

EVAN: Evangelista, A.M. Behavioral Toxicology, Risk Assessment, and Chlorinated Hydrocarbons. Environmental. Health Perspectives. 104 (Supplement 2): 353-360. 1996. (Table 1: Comparison of behavioral toxicity of chlorinated hydrocarbons and related compounds).

FELD: Feldman, R.G. Role of the Neurologist in Hazard Identification and Risk Assessment. Environmental Health Perspectives. 104 (Supplement 2):227-237. 1996. (Table 1: Neurologic symptoms and associated exposures).

HAZMAP: A Relational Database of Hazardous Chemicals and Occupational Diseases. Browse Haz-Map by Adverse Effects: Neurotoxin.

KLAA: Klaassen, C., M. Amdur and J. Doull (eds.). Casarett and Doull's Toxicology. The Basic Science of Poisons, 5th Ed. Pergamon Press, NY. 1996. (Tables 16-1: Compounds Associated with Neuronal Injury, Table 16-2: Compounds Associated with Axonal Injury, Table 16-3: Compounds Associated with Injury of Myelin).

LU: Lu, F.C. Basic Toxicology. 2nd Edition. 1991. (Appendix 16-1: Selected Neurotoxicants).

MASL: Massachusetts Department of Public Health. Commonwealth of Massachusetts. 105CMR 670.000 Administrative Bulletin Concerning Massachusetts Substance List for "Right to Know" Law, M.G.L. 111F. 4/24/93. (Appendix A: Massachusetts Substance List)

NJ-FS: New Jersey Department of Health Services. Right to Know Program, NJDOH, Trenton, NJ.

NTP-HS: National Toxicology Program. Chemical Repository of Health and Safety Data.[Insert CAS#].txt

OEHHA-AREL: California EPA, Office of Environmental Health Hazard Assessment. Acute Reference Exposure Levels (RELs), Averaging Times, and Toxicologic Endpoints. Includes all Acute Reference Exposure Levels (ARELs) developed by OEHHA through May 2000

OEHHA-CREL: California EPA, Office of Environmental Health Hazard Assessment. Air Toxics Hot Spots Program Risk Assessment Guidelines, Part III: Technical Support Document "Determination of Noncancer Chronic Reference Exposure Levels". Includes all Chronic Reference Exposure Levels (CRELs) adopted by OEHHA as of August 2003 (, plus draft CRELS proposed through March 2004 (

RTECS: National Institute for Occupational Safety and Health's Registry of Toxic Effects of Chemical Substances. See Environmental Defense's Suspect Hazard Identification documentation.

STAC: Stacey, N.H. Occupational Toxicology. Taylor & Francis. 1995. (Table 3.9: Occupational diseases - brain and spinal cord, Table 3.10: Occupations associated with an excess of brain cancer, Table 3.11: Agents capable of producing brain cancer in experimental animals, Table 3.12: Occupational diseases - mental disorders, Table 3.14: Agents causing occupational neuropathy).

TANN: Tanner, C. Occupational and Environmental Causes of Parkinsonism. Occupational Medicine 7(3): 5-3-513. (Table 2: Occupational and Environmental Causes of Parkinsonism).

ZAKR: Zakrzewski, S.F. Principles of Environmental Toxicology. American Chemical Society, Washington, DC. 1997. (Table 7.4: TLV-TWA Values of Some Neurotoxins).