HEALTH EFFECTS|Immunotoxicity References

Immunotoxicity References
There is no generally accepted source for an authoritative list of chemicals that are recognized to cause immunotoxicity.

Environmental Defense's list of suspect immunotoxicants is compiled from the following sources:

ATSDR: Agency for Toxic Substances and Disease Registry. Minimal risk Levels for Hazardous Substances. January 2004.

ATSDR-FAQ: Agency for Toxic Substances and Disease Registry. ToxFAQs.

CAA-AQC: US EPA, Office of Research and Development. Air Quality Criteria for Oxides of Nitrogen, Volume III Washington, DC. August 1993.

EDF: See Environmental Defense's Custom Hazard Identification documentation.

EEC: European Economic Community. Sensitizing Substances in the EEC List of Dangerous Substances. Annex I to Council Directive 67/548/EEC.

EPA-HEN: US EPA, Air Risk Information Support Center. Health Effects Notebook for Hazardous Air Pollutants.

EPA-TRI: US EPA. Addition of Certain Chemicals; Toxic Chemical Release Reporting; Community Right to Know. Proposed and Final Rules. 59 Federal Register 1788 (Jan 12, 1994); 59 Federal Register 61432 (November 30, 1994). Summarized in Hazard Information on Toxic Chemicals Added to EPCRA Section 313 Under Chemical Expansion.

HAZMAP: A Relational Database of Hazardous Chemicals and Occupational Diseases. Browse Haz-Map by Adverse Effects: Dermatotoxin - Skin Sensitizer or Photoallergic Contact Dermatitis.

IPCS: nternational Programme of Chemical Safety Environmental Health Criteria 180. Principles and Methods for Assessing Direct Immunotoxicity Associated with Exposure to Chemicals. World Health Organization. Geneva, 1996. (Table 1: Examples of compounds that are immunotoxic for humans or rodents).

NAP: Nordic Council of Ministers (Nordic Allergy Project). Kriteriedokumenter fra nordisk allergiprojekt - vurdering af 50 kemiske stoffers evne til at forarsage allergi, en litteraturgennemgang. Nord 1991:51. Copenhagen, 1991.

NTP-I: National Toxicology Program. Summary Reports on Immunotoxicity.

OEHHA-AREL: California EPA, Office of Environmental Health Hazard Assessment. Acute Reference Exposure Levels (RELs), Averaging Times, and Toxicologic Endpoints. Includes all Acute Reference Exposure Levels (ARELs) developed by OEHHA through May 2000

OEHHA-CREL: California EPA, Office of Environmental Health Hazard Assessment. Air Toxics Hot Spots Program Risk Assessment Guidelines, Part III: Technical Support Document "Determination of Noncancer Chronic Reference Exposure Levels". Includes all Chronic Reference Exposure Levels (CRELs) adopted by OEHHA as of August 2003 (, plus draft CRELS proposed through March 2004 (

RTECS: National Institute for Occupational Safety and Health's Registry of Toxic Effects of Chemical Substances. See Environmental Defense's Suspect Hazard Identification documentation.

SNCI: Swedish National Chemicals Inspectorate. Labelling of chemical products, Swedish regulations and general advice with regard to the classification and labelling of chemical products hazardous to health, flammables and explosives. List of Allergenic Substances. National Chemicals Inspectorate, Solna, Sweden. 1987, 1990-1992.