HEALTH EFFECTS|Cancer References

Cancer References
P65: The most current and authoritative list of chemicals that are recognized to cause cancer is California's Proposition 65. Substances are placed on the Proposition 65 list of chemicals "known to the state of California to cause cancer" if an independent science advisory board has concluded they possess sufficient evidence of carcinogenicity in animals or humans, or if an authoritative organization such as the International Agency for Research on Cancer or the National Toxicology Program have reached a similar conclusion, or if a federal regulatory agency requires a cancer warning label. The current Proposition 65 List of Carcinogens (July 2004) can be obtained from http://www.oehha.ca.gov/prop65/prop65_list/Newlist.html.

A number of chemicals have toxicological evidence of carcinogenicity that currently does not satisfy the sufficiency criteria used to list agents under Proposition 65, or that has not yet been finally evaluated by the carcinogen identification processes in the state of California or other authoritative agencies.

Environmental Defense's list of suspect carcinogens is compiled from the following sources:

CPDB: Carcinogenic Potency Database. http://potency.berkeley.edu/app14.html
Environmental Defense reviewed this compilation of results on carcinogenicity in rats and mice covering 1298 chemicals and added any chemical with positive results in at least two species by a relevant route of exposure to its list of suspect carcinogens.

EDF: See Environmental Defense's Custom Hazard Identification documentation.

EPA-HEN: US EPA, Air Risk Information Support Center. Health Effects Notebook for Hazardous Air Pollutants. http://www.epa.gov/ttnatw01/hlthef/hapindex.html

EPA-TRI: US EPA. Addition of Certain Chemicals; Toxic Chemical Release Reporting; Community Right to Know. Proposed and Final Rules. 59 Federal Register 1788 (Jan 12, 1994); 59 Federal Register 61432 (November 30, 1994). Summarized in Hazard Information on Toxic Chemicals Added to EPCRA Section 313 Under Chemical Expansion. http://www.epa.gov/tri/chemical/hazard_cx.htm

HAZMAP: A Relational Database of Hazardous Chemicals and Occupational Diseases. Browse Haz-Map by Adverse Effects: Carcinogen (Known, Probable, Possible) and Lung Toxin-Lung Cancer. http://hazmap.nlm.nih.gov/hazmapadv.html

IARC: World Health Organization, International Agency for Research on Cancer. IARC Monographs Programme on the Evaluation of Carcinogenic Risks to Humans. Lists of Group 1, 2a, and 2b substances can be obtained at http://monographs.iarc.fr/monoeval/grlist.html.

IRIS: US EPA, National Center for Environmental Assessment. Integrated Risk Information System. http://www.epa.gov/iriswebp/iris/index.html

NTP-BR: National Toxicology Program. Summary for Agents, Substances, Mixtures or Exposure Circumstances to be Reviewed in 2001-2002 for Possible Listing in the Report on Carcinogens, Eleventh Edition. NTP Board of Scientific Counselors, NTP, Research Triangle Park, NC.http://ntp-server.niehs.nih.gov/NewHomeRoc/11thConsideration.html
National Toxicology Program. Summary for Agents, Substances, Mixtures or Exposure Circumstances to be Reviewed in 2004-2005 for Possible Listing in the Report on Carcinogens, Twelfth Edition. NTP Board of Scientific Counselors, NTP, Research Triangle Park, NC. http://ntp-server.niehs.nih.gov/NewHomeRoc/12thConsideration.html

NTP-C: National Toxicology Program. 10th Report on Carcinogens (2002). http://ehis.niehs.nih.gov/roc/toc10.html

NTP-HS: National Toxicology Program. Chemical Repository of Health and Safety Data. http://ntp-db.niehs.nih.gov/NTP_Reports/NTP_Chem_H&S/NTP_Chem8/Radian[Insert CAS#].txt

OEHHA-TCD: California Environmental Protection Agency, Office of Environmental Health Hazard Assessment. Toxicity Criteria Database - OEHHA Cancer Potency Values . http://www.oehha.ca.gov/risk/pdf/60204cascpl.pdf.

OPP-CAN: US EPA, Office of Pesticide Programs. List of Chemicals Evaluated for Carcinogenic Potential (5/10/2002). OPP, Washington, DC. http://www.epi.uci.edu/valleycenter/EPAListCarcinogenicChemicals.pdf

ORD-SF: US EPA, Office of Research and Development, Superfund Health Risk Technical Support Center. Risk Assessment Issue Paper for: Toxicity Information and Provisional Oral Slope Factor for Nitroglycerin. ORD, Washington, DC.

P65-CAND: California EPA, Office of Environmental Health Hazard Assessment. Prioritization Notices. http://www.oehha.org/prop65/CRNR_notices/state_listing/prioritization_notices/index.html.
Chemicals on Candidate List for consideration under Proposition 65 due to high carcinogenicity concern (through March 2004).
Chemicals under consideration for listing via the authoritative bodies mechanisms (through July 2004).

P65-MC: Hazard identification based on an extension of a Proposition 65 listing. Substance is either a member of a class that is a recognized Proposition 65 hazard, or is a class that contains a member that is a recognized Propositon 65 hazard. See Environmental Defense's Member Class Hazard Identification documentation.

P65-PEND: California EPA, Office of Environmental Health Hazard Assessment. Notices of Intent to List . http://www.oehha.org/prop65/CRNR_notices/admin_listing/intent_to_list/index.html.
Chemicals noticed for listing under Proposition 65 because a body considered to be authoritative by the state's qualified experts has formally identified it as causing cancer (through July 2004).

SCDM: US EPA, Office of Emergency Response and Remediation. Superfund Chemical Data Matrix. http://www.epa.gov/superfund/resources/scdm/index.htm

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