HEALTH EFFECTS|Reproductive Toxicants

Reproductive Toxicants
Exposure to chemical substances can cause adverse effects on the male and female reproductive systems. Reproductive toxicity may be expressed as alterations in sexual behavior, decreases in fertility, or loss of the fetus during pregnancy. A reproductive toxicant may interfere with the sexual functioning or reproductive ability of exposed individuals from puberty throughout adulthood. Toxicants that target the female reproductive system can cause a wide variety of adverse effects. Changes in sexual behavior, onset of puberty, cyclicity, fertility, gestation time, pregnancy outcome, and lactation as well as premature menopause are among the potential manifestations of female reproductive toxicity: all can disrupt a womanÂ’s ability to successfully reproduce. Exposure to lead, for example, can result in menstrual disorders and infertility. The toxicants carbon disulfide, mercury, and polychlorinated biphenyls (PBCs) have been shown to cause irregularities in the menstrual cycle. Toxicants that target the male reproductive system can affect sperm count or shape, alter sexual behavior, and/or increase infertility. Carbon disulfide and the pesticides chlordecone (kepone), ethylene dibromide (EDB), and dibromochloropropane (DBCP) are examples of chemicals known to disrupt male reproductive health.

References used to compile the list of Reproductive Toxicants

Recognized Reproductive Toxicants
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Chemical Name CAS Registry Number (or EDF Substance ID) Reference(s)
(1,2-BENZENEDICARBOXYLATO(2-))DIOXOTRILEAD69011-06-9P65-MC
1,2-DIBROMO-3-CHLOROPROPANE (DBCP)96-12-8P65
1,2-DIBROMOETHANE106-93-4P65
1,3-BUTADIENE106-99-0P65
2,3-DINITROTOLUENE602-01-7P65-MC
2,4-DB94-82-6P65
2,4-DINITROTOLUENE121-14-2P65
2,5-DINITROTOLUENE619-15-8P65-MC
2,6-DINITROTOLUENE606-20-2P65
3,4-DINITROTOLUENE610-39-9P65-MC
ACETYLSALICYLIC ACID50-78-2P65
ADRIAMYCIN23214-92-8P65
ALKYL LEAD COMPOUNDSEDF-171P65-MC
AMINOPTERIN54-62-6P65
AMIODARONE HYDROCHLORIDE19774-82-4P65
ANABOLIC STEROIDSEDF-006P65
BENOMYL17804-35-2P65
BENZENE71-43-2P65
BIS(2-ETHYLHEXYL)PHTHALATE117-81-7P65
BROMACIL LITHIUM SALT (2,4(H,3H)-PYRIMIDINEDIONE, ETHYL-3 (1-METHYLPROPYL), LITHIUM SALT)53404-19-6P65
CADMIUM7440-43-9P65
CARBON DISULFIDE75-15-0P65
CHLORSULFURON64902-72-3P65
CHROMIUM LEAD SILICATE11113-70-5P65-MC
CIDOFOVIR113852-37-2P65
CLOBETASOL PROPIONATE25122-46-7P65
COCAINE50-36-2P65
COLCHICINE64-86-8P65
CYCLO-DI-:-OXO(:-PHTHALATO)TRILEAD17976-43-1P65-MC
CYCLOPHOSPHAMIDE50-18-0P65
CYCLOPHOSPHAMIDE (HYDRATED)6055-19-2P65
DDT50-29-3P65
DIFLUNISAL22494-42-4P65
DINITROBENZENE25154-54-5P65-MC
DINITROBUTYL PHENOL88-85-7P65
DINITROTOLUENE (MIXED ISOMERS)25321-14-6P65
EPICHLOROHYDRIN106-89-8P65
ETHYLENE GLYCOL MONOETHYL ETHER110-80-5P65
ETHYLENE GLYCOL MONOETHYL ETHER ACETATE111-15-9P65
ETHYLENE GLYCOL MONOMETHYL ETHER109-86-4P65
ETHYLENE GLYCOL MONOMETHYL ETHER ACETATE110-49-6P65
ETHYLENE OXIDE75-21-8P65
ETODOLAC41340-25-4P65
FLUNISOLIDE3385-03-3P65
FLUOROACETIC ACID, SODIUM SALT62-74-8P65
FLURBIPROFEN5104-49-4P65
GANCICLOVIR SODIUM82410-32-0P65
GEMFIBORZIL25812-30-0P65
GOSERELIN ACETATE65807-02-5P65
HALOPERIDOL52-86-8P65
HEXAMETHYLPHOSPHORAMIDE680-31-9P65
HYDRAMETHYLNON67485-29-4P65
IDARUBICIN HYDROCHLORIDE57852-57-0P65
INORGANIC LEAD COMPOUNDS1128P65-MC
LEAD7439-92-1P65
LEAD (ALKYL 4+) (SOLNR LEAD ALKYLS)EDF-199P65-MC
LEAD ACETATE301-04-2P65-MC
LEAD ARSENATE7784-40-9P65-MC
LEAD ARSENITE10031-13-7P65-MC
LEAD CHLORIDE7758-95-4P65-MC
LEAD CHROMATE7758-97-6P65-MC
LEAD CHROMATE OXIDE18454-12-1P65-MC
LEAD COMPOUNDSLCT000P65
LEAD DIOXIDE1309-60-0P65-MC
LEAD FLUOBORATE13814-96-5P65-MC
LEAD FLUORIDE7783-46-2P65-MC
LEAD II ARSENATE7645-25-2P65-MC
LEAD IODIDE10101-63-0P65-MC
LEAD NITRATE10099-74-8P65-MC
LEAD PHOSPHATE7446-27-7P65-MC
LEAD SILICATE11120-22-2P65-MC
LEAD STEARATE7428-48-0P65-MC
LEAD SUBACETATE1335-32-6P65-MC
LEAD SULFATE7446-14-2P65-MC
LEAD SULFIDE1314-87-0P65-MC
LEAD THIOCYANATE592-87-0P65-MC
LEAD(II) OXIDE1317-36-8P65-MC
LEAD-MOLYBDENUM CHROMATE12709-98-7P65-MC
LEUPROLIDE ACETATE74381-53-6P65
LEVONORGESTREL IMPLANTS797-63-7P65
M-DINITROBENZENE99-65-0P65
MELAMINE, HEXAMETHYL-645-05-6P65
MYCLOBUTANIL88671-89-0P65
NIFEDIPINE21829-25-4P65
NITROFURANTOIN67-20-9P65
O,P'-DDT789-02-6P65
O-DINITROBENZENE528-29-0P65
ORGANIC LEAD COMPOUNDSEDF-230P65-MC
OXYDEMETON METHYL301-12-2P65
P-DINITROBENZENE100-25-4P65
PACLITAXEL33069-62-4P65
PIMOZIDE2062-78-4P65
QUIZALOFOP-ETHYL76578-14-8P65
RIBAVIRIN36791-04-5P65
RIFAMPICIN13292-46-1P65
SALICYLAZOSULFAPYRIDINE599-79-1P65
STREPTOZOTOCIN18883-66-4P65
SULINDAC38194-50-2P65
TECHNICAL GRADE 2,4 & 2,6 DINITROTOLUENEEDF-210P65-MC
TETRAETHYLLEAD78-00-2P65-MC
TETRAMETHYL LEAD75-74-1P65-MC
THIOPHANATE-METHYL23564-05-8P65
TOBACCO SMOKE (PRIMARY)EDF-073P65
TRIADIMEFON43121-43-3P65
URACIL MUSTARD66-75-1P65
ZILEUTON111406-87-2P65

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