HEALTH EFFECTS|Reproductive Toxicants

Reproductive Toxicants
Exposure to chemical substances can cause adverse effects on the male and female reproductive systems. Reproductive toxicity may be expressed as alterations in sexual behavior, decreases in fertility, or loss of the fetus during pregnancy. A reproductive toxicant may interfere with the sexual functioning or reproductive ability of exposed individuals from puberty throughout adulthood. Toxicants that target the female reproductive system can cause a wide variety of adverse effects. Changes in sexual behavior, onset of puberty, cyclicity, fertility, gestation time, pregnancy outcome, and lactation as well as premature menopause are among the potential manifestations of female reproductive toxicity: all can disrupt a womanÂ’s ability to successfully reproduce. Exposure to lead, for example, can result in menstrual disorders and infertility. The toxicants carbon disulfide, mercury, and polychlorinated biphenyls (PBCs) have been shown to cause irregularities in the menstrual cycle. Toxicants that target the male reproductive system can affect sperm count or shape, alter sexual behavior, and/or increase infertility. Carbon disulfide and the pesticides chlordecone (kepone), ethylene dibromide (EDB), and dibromochloropropane (DBCP) are examples of chemicals known to disrupt male reproductive health.

References used to compile the list of Reproductive Toxicants


Suspected Reproductive Toxicants Note: For your convenience, these data are also available as a CSV file. Click here to download.
Chemical Name CAS Registry Number (or EDF Substance ID) Reference(s)
(RS)-2-(3,5-DICHLOROPHENYL)-2-(2,2,2-TRICHLOROETHYL)OXIRANE58138-08-2JANK
1,1,1-TRICHLOROETHANE71-55-6EPA-SARA, FRAZIER
1,1-DICHLOROETHYLENE75-35-4EPA-SARA
1,2,3-TRICHLOROPROPANE96-18-4NTP-R
1,2-DICHLOROETHANE107-06-2EPA-SARA
1,2-DICHLOROPROPANE78-87-5FRAZIER
1,3,5-TRIAZINE-2,4,6(1H,3H,5H)-TRIIMINE108-78-1EPA-SARA
1,3-DICHLOROPROPENE (MIXED ISOMERS)542-75-6FRAZIER
1-BROMOPROPANE106-94-5CERHR, P65-CAND
1-CARBOXY-4-NITROBENZENE62-23-7NTP-R
1-HYDROXY-2-PHENOXYETHANE122-99-6NTP-R
2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN (TCDD)1746-01-6OEHHA-CREL
2,3-EPOXY 1-PROPANOL556-52-5JANK
2,4,5-T93-76-5HAZMAP, JANK
2,4-D94-75-7EPA-SARA, FRAZIER, HAZMAP, JANK
2,4-DIAMINOTOLUENE95-80-7JANK
2,4-DINITROPHENOL51-28-5EPA-SARA
2-BROMOPROPANE75-26-3CERHR
2-BUTOXYETHANOL ACETATE112-07-2HAZMAP
2-CHLOR-1,3-BUTADIENE126-99-8EPA-SARA, FRAZIER, HAZMAP
2-NITROPROPANE79-46-9EPA-SARA
2-PHENYLPHENOL90-43-7EPA-SARA
4,4'-DIAMINODIPHENYL SULFIDE139-65-1EPA-SARA
4,4'-ISOPROPYLIDENEDIPHENOL80-05-7JANK, NTP-R
4-VINYLCYCLOHEXENE100-40-3NTP-R
7,12-DIMETHYLBENZ(A)ANTHRACENE57-97-6JANK
ACETONITRILE75-05-8EPA-SARA
ACRYLAMIDE79-06-1EPA-SARA, FRAZIER, JANK, NTP-R
ACRYLONITRILE107-13-1ATSDR, EPA-SARA
AF-2; [2-(2-FURYL)-3-(5-NITRO-2-FURYL)]ACRYLAMIDE3688-53-7JANK
ALDICARB116-06-3FRAZIER
ALDRIN309-00-2EPA-SARA
ALUMINUM7429-90-5FRAZIER
ALUMINUM CHLORIDE7446-70-0JANK
AMMONIA7664-41-7FRAZIER
ANTIMONY7440-36-0EPA-SARA, FRAZIER
AROCLOR 124253469-21-9HAZMAP
AROCLOR 125411097-69-1HAZMAP
ARSENIC7440-38-2FRAZIER, OEHHA-AREL
ARSINE7784-42-1FRAZIER
ATRAZINE1912-24-9ATSDR, JANK
BARIUM7440-39-3FRAZIER
BENZYL BUTYL PHTHALATE85-68-7CERHR
BERYLLIUM7440-41-7FRAZIER
BETA-LINDANE319-85-7OEHHA-CREL
BORIC ACID10043-35-3FRAZIER, JANK, NTP-R
CADMIUM COMPOUNDSCAE750P65-MC
CAMPHECHLOR8001-35-2EPA-SARA
CAPTAN133-06-2EPA-SARA, FRAZIER
CARBARYL63-25-2EPA-SARA, FRAZIER
CARBOFURAN1563-66-2JANK
CARBON DIOXIDE124-38-9JANK
CARBON MONOXIDE630-08-0FRAZIER, HAZMAP, JANK
CARBON TETRACHLORIDE56-23-5OEHHA-AREL
CHLORATEEDF-204FRAZIER
CHLORDANE57-74-9EPA-SARA
CHLORDECONE (KEPONE)143-50-0FRAZIER, HAZMAP
CHLORHYDRIN96-24-2JANK
CHLORINE DIOXIDE10049-04-4EPA-SARA, FRAZIER
CHLORITEEDF-205FRAZIER
CHLOROBENZENE108-90-7EPA-SARA, JANK, OEHHA-CREL
CHLOROBENZILATE510-15-6EPA-SARA
CHLOROFORM67-66-3EPA-SARA, FRAZIER, OEHHA-AREL
CHLOROMETHANE74-87-3EPA-SARA, FRAZIER, JANK, P65-PEND
CHLORPYRIFOS2921-88-2FRAZIER
CHROMIUM7440-47-3FRAZIER
COBALT7440-48-4FRAZIER
COPPER7440-50-8EPA-SARA, FRAZIER
CYCLOHEXANOL108-93-0EPA-TRI
CYCLOHEXYLAMINE108-91-8JANK
CYCLONITE121-82-4ATSDR
CYFLUTHRIN68359-37-5FRAZIER
CYPERMETHRIN52315-07-8FRAZIER
DDT (TOTAL)EDF-229P65-MC
DEET134-62-3FRAZIER
DI-N-HEXYLPHTHALATE84-75-3CERHR, NTP-R, P65-CAND
DI-N-PENTYL PHTHALATE131-18-0NTP-R
DIALLATE2303-16-4EPA-SARA
DIAZINON333-41-5FRAZIER
DIBENZOFURANS (CHLORINATED)1080OEHHA-CREL
DIBUTYL PHTHALATE84-74-2EPA-SARA, NTP-R, P65-CAND
DICAMBA1918-00-9FRAZIER
DICHLOROFLUOROMETHANE75-43-4KEMI-DAN
DICHLOROMETHANE75-09-2FRAZIER, JANK
DICHLORVOS62-73-7EPA-SARA
DIELDRIN60-57-1JANK
DIETHYL PHTHALATE84-66-2ATSDR
DIETHYLENE GLYCOL ETHER111-46-6NTP-R
DIETHYLENE GLYCOL MONOBUTYL ETHER112-34-5HAZMAP
DIETHYLSTILBESTROL56-53-1NTP-R
DINOCAP39300-45-3HAZMAP
DIPROPYL PHTHALATE131-16-8NTP-R
DIPROPYLENE GLYCOL MONOMETHYL ETHER34590-94-8HAZMAP
ENDRIN72-20-8JANK
ENFLURANE13838-16-9FRAZIER, HAZMAP
ERGOCALCIFEROL50-14-6JANK
ETHANOL64-17-5FRAZIER
ETHIDIUM BROMIDE1239-45-8FRAZIER
ETHOXYACETIC ACID627-03-2NTP-R
ETHYL DIPROPYLTHIOCARBAMATE759-94-4EPA-TRI
ETHYL METHANESULFONATE62-50-0JANK
ETHYLBENZENE100-41-4EPA-SARA
ETHYLENE GLYCOL107-21-1JANK, NTP-R
ETHYLENE GLYCOL MONOBUTYL ETHER111-76-2HAZMAP
ETHYLENE THIOUREA96-45-7EPA-SARA
ETHYLENEIMINE151-56-4EPA-SARA
FAMCICLOVIR104227-87-4P65-CAND
FELODIPINE72509-76-3P65-CAND
FLUOXETINE54910-89-3CERHR
FLUOXETINE HYDROCHLORIDE59333-67-4CERHR
FLUVASTATIN SODIUMEDF-004P65-CAND
FORMALDEHYDE50-00-0EPA-SARA, FRAZIER
FORMAMIDE75-12-7JANK, NTP-R
GAMMA-LINDANE58-89-9EPA-SARA, FRAZIER, JANK
GLUTARALDHYDE111-30-8FRAZIER
GLYCIDYL ETHERSEDF-509FRAZIER
GLYCOL ETHERSEDF-109HAZMAP, P65-MC
GLYPHOSATE1071-83-6FRAZIER
GOSSYPOL303-45-7JANK
GOSSYPOL ACETIC ACID12542-36-8JANK
HALOTHANE151-67-7FRAZIER, HAZMAP
HEAVY METALSEDF-380P65-MC
HEPTACHLOR76-44-8EPA-SARA
HEXACHLORO-1,3-BUTADIENE87-68-3EPA-SARA
HEXACHLOROBENZENE118-74-1ATSDR, EPA-SARA, FRAZIER
HEXACHLOROCYCLOPENTADIENE77-47-4EPA-SARA
HEXACHLOROETHANE67-72-1EPA-SARA
HEXAFLUOROACETONE684-16-2HAZMAP
HYDRAZINE302-01-2FRAZIER
HYDROFLUORIC ACID7664-39-3EPA-SARA
HYDROGEN CYANIDE74-90-8FRAZIER
HYDROGEN SULFIDE7783-06-4FRAZIER
HYDROQUINONE123-31-9FRAZIER
INDIUM7440-74-6FRAZIER
IRON7439-89-6FRAZIER
ISOCYANATES1125FRAZIER
ISOPROPOXYETHANOL109-59-1HAZMAP
M-NITROBENZOIC ACID121-92-6NTP-R
MALATHION121-75-5FRAZIER
MANEB12427-38-2EPA-SARA
MANGANESE7439-96-5EPA-HEN, EPA-SARA, FRAZIER, HAZMAP
MANGANESE COMPOUNDSMAR500EPA-HEN
MANGANESE TETROXIDE1317-35-7HAZMAP
MECHLORETHAMINE51-75-2EPA-SARA
MERCURY7439-97-6EPA-SARA, FRAZIER, HAZMAP, OEHHA-AREL
METALSEDF-035P65-MC
METHOXYCHLOR72-43-5ATSDR, EPA-HEN, EPA-SARA, JANK
METHOXYFLURANE76-38-0HAZMAP
METHYL BROMIDE74-83-9FRAZIER
METHYL ETHYL KETONE78-93-3EPA-SARA, FRAZIER
METHYL ISOCYANATE624-83-9EPA-HEN, EPA-SARA, OEHHA-CREL
METHYL METHACRYLATE80-62-6EPA-SARA
METHYL METHANESULFONATE66-27-3JANK
METHYOXYACETIC ACID625-45-6NTP-R
MOLINATE2212-67-1EPA-TRI
MOLYBDENUM7439-98-7FRAZIER
MUSTARD GAS505-60-2JANK
N,N'-METHYLENEBISACRYLAMIDE110-26-9NTP-R
N,N-DIMETHYLFORMAMIDE68-12-2FRAZIER, NTP-R
N-ETHYL-N-NITROSOUREA759-73-9EPA-SARA
N-HEXANE110-54-3FRAZIER
N-METHYL-2-PYRROLIDONE872-50-4EPA-TRI, FRAZIER, P65-PEND
N-METHYLOLACRYLAMIDE924-42-5NTP-R
N-NITROSODIETHYLAMINE55-18-5EPA-SARA
NALED300-76-5EPA-TRI
NICKEL7440-02-0EPA-SARA, FRAZIER, JANK
NICKEL (II) CHLORIDE37211-05-5JANK
NICKEL CARBONYL13463-39-3JANK
NICKEL COMPOUNDSNDB000JANK
NITRATE14797-55-8FRAZIER
NITRITE14797-65-0FRAZIER
NITROBENZENE98-95-3EPA-SARA
NITROFEN1836-75-5EPA-SARA
NITROFURAZONE59-87-0JANK, NTP-R
NITROGEN DIOXIDE10102-44-0JANK
NITROUS OXIDE10024-97-2FRAZIER
O-XYLENE95-47-6EPA-SARA
OCTACHLORONAPHTHALENE2234-13-1EPA-SARA
ORGANOCHLORINE PESTICIDESEDF-175P65-MC
ORGANOPHOSPHATE PESTICIDESEDF-163P65-MC
OXALIC ACID144-62-7NTP-R
P-XYLENE106-42-3EPA-SARA
PARAQUAT1910-42-5FRAZIER
PARATHION56-38-2EPA-SARA
PENTACHLOROPHENOL87-86-5ATSDR, EPA-SARA
PENTAMIDINE140-64-7FRAZIER
PENTOBARBITAL SODIUM57-33-0EPA-TRI
PERMETHRIN52645-53-1FRAZIER
PHENOL108-95-2FRAZIER, P65-CAND
PHENOLPHTHALEIN77-09-8NTP-R
PHOSPHORUS (YELLOW OR WHITE)7723-14-0ATSDR, EPA-SARA, OEHHA-CREL
PHTHALATESEDF-150FRAZIER, P65-MC
PIPERONYL BUTOXIDE51-03-6JANK
PLUTONIUM7440-07-5HAZMAP
PM 10EDF-077P65-MC
PM 2.5EDF-213P65-MC
POLYBROMINATED BIPHENYLSPJL335FRAZIER, HAZMAP
POLYCHLORINATED BIPHENYLS1336-36-3EPA-SARA, FRAZIER
POLYCYCLIC AROMATIC COMPOUNDS65996-93-2FRAZIER
PROPANTHELINE BROMIDE50-34-0NTP-R
PROPOXUR114-26-1JANK
PROPYLENE GLYCOL MONOMETHYL ETHER107-98-2HAZMAP
PROPYLENE OXIDE75-56-9EPA-SARA
QUINTOZENE82-68-8EPA-SARA
SACCHARIN81-07-2EPA-SARA
SAFROLE94-59-7EPA-SARA
SELENIUM7782-49-2EPA-SARA, FRAZIER, HAZMAP
SELENIUM COMPOUNDSSBP500HAZMAP
SODIUM AZIDE26628-22-8FRAZIER
SODIUM CYANIDE143-33-9ATSDR
STYRENE100-42-5FRAZIER
STYRENE OXIDE96-09-3EPA-SARA
SULFAMETHAZINE57-68-1NTP-R
TELLURIUM13494-80-9FRAZIER
TETRACHLOROETHYLENE127-18-4EPA-SARA, FRAZIER, JANK
THALLIUM7440-28-0FRAZIER
THEOBROMINE83-67-0NTP-R
THEOPHYLLINE58-55-9NTP-R
THIOUREA62-56-6EPA-SARA
TIN7440-31-5FRAZIER
TITANIUM DIOXIDE13463-67-7FRAZIER
TOLUENE108-88-3EPA-SARA, FRAZIER
TRIAZIQUONE68-76-8EPA-SARA
TRICHLORFON52-68-6EPA-SARA
TRICHLOROETHYLENE79-01-6EPA-SARA, FRAZIER
TRICRESYL PHOSPHATE1330-78-5NTP-R
TRIETHYLENE GLYCOL DIMETHYL ETHER112-49-2NTP-R
TRIETHYLENEMELAMINE51-18-3JANK
TRIFLURALIN1582-09-8EPA-SARA
TRIMETHYL PHOSPHATE512-56-1JANK
TRIORTHOCRESYL PHOSPATE78-30-8NTP-R
TRIPHENYLTIN CHLORIDE639-58-7EPA-TRI
TRIS(2,3-DIBROMOPROPYL) PHOSPHATE126-72-7EPA-SARA
TRIS(2-CHLOROETHYL) PHOSPHATE115-96-8NTP-R
TUNGSTEN METAL7440-33-7FRAZIER
URANIUM7440-61-1FRAZIER
VANADIUM OXIDE (5)1314-62-1FRAZIER
VINYL CHLORIDE75-01-4EPA-SARA, FRAZIER, HAZMAP
VISIBILITY REDUCING PARTICULATESEDF-214P65-MC
VOLATILE ORGANIC COMPOUNDSEDF-111P65-MC
WINTERGREEN OIL119-36-8NTP-R
WOOD PRESERVATIVES (CONTAINING ARSENIC & CHROMATE)1206P65-MC
XYLENE (MIXED ISOMERS)1330-20-7EPA-SARA, FRAZIER, HAZMAP
ZEARALENONE17924-92-4P65-PEND
ZINC7440-66-6EPA-SARA
ZINC CHLORIDE FUME7646-85-7FRAZIER
ZINC OXIDE1314-13-2FRAZIER
ZINEB12122-67-7EPA-SARA

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