HEALTH EFFECTS|Endocrine Toxicants

Endocrine Toxicants
Exposure to chemical substances can cause adverse effects on the endocrine system, which is comprised of the organs and glands that secrete hormones (Endocrine Toxicity). Hormones control normal physiological processes, maintaining the body's homeostasis. Compounds that are toxic to the endocrine system may cause diseases such as hypothyroidism, diabetes mellitus, hypoglycemia, reproductive disorders, and cancer.

Exposure to endocrine-disrupting chemicals such as polychlorinated biphenyls (PCBs) and DDT have caused a host of toxic effects in wildlife, including impaired reproduction and development. Other endocrine toxicants, such as persistent organochlorine pesticides and dioxins, are being studied for their possible role in promoting hormone-induced cancers (such as breast cancer) and in lowering sperm counts and male fertility.

References used to compile the list of Endocrine Toxicants


Suspected Endocrine Toxicants Note: For your convenience, these data are also available as a CSV file. Click here to download.
Chemical Name CAS Registry Number (or EDF Substance ID) Reference(s)
(1,1,3,3-TETRAMETHYLBUTYL)PHENOL27193-28-8JNIHS
1,1'-OXYBISBENZENE PENTABROMO DERIV.32534-81-9ATSDR
1,2,3,4,5,6-HEXACHLOROCYCLOHEXANE (MIXTURE OF ISOMERS)608-73-1IL-EPA, WWF
1,2,3,4,6,7,8,9-OCTACHLORODIBENZOFURAN39001-02-0IL-EPA
1,2,3,4,6,7,8-HEPTACHLORODIBENZO-P-DIOXIN35822-46-9IL-EPA
1,2,3,7,8,9-HEXACHLORODIBENZO-P-DIOXIN19408-74-3IL-EPA
1,2,3,7,8-PENTACHLORODIBENZO-P-DIOXIN40321-76-4BKH
1,2,3,7,9-PENTACHLORODIBENZOFURANEDF-502WWF
1,2,3-TRITHIAN-5-AMINE, N,N-DIMETHYL-, ETHANEDIOATE (1:1)31895-22-4RTECS
1,2-BENZENEDICARBOXYLIC ACID, DICYCLOHEXYL ESTER84-61-7JNIHS
1,2-BENZENEDICARBOXYLIC ACID, DIISODECYL ESTER26761-40-0JNIHS
1,2-BENZENEDICARBOXYLIC ACID, DIISONONYL ESTER28553-12-0JNIHS
1,2-BENZENEDICARBOXYLIC ACID, DITRIDECYL ESTER119-06-2JNIHS
1,2-DIBROMO-3-CHLOROPROPANE (DBCP)96-12-8IL-EPA, JNIHS, KEIT
1,2-DIBROMOETHANE106-93-4JNIHS, WWF
1,2-DICHLOROBENZENE95-50-1RTECS
1,2-DICHLOROPROPANE78-87-5RTECS
1,3,6,8-TETRACHLO-RODIBENZOFURANEDF-504WWF
1,5-NAPHTHALENEDIAMINE2243-62-1RTECS
1-(P-HYDROXYPHENYL)OCTANE1806-26-4IL-EPA, JNIHS
1-AMINO-2-CHLOROBENZENE95-51-2RTECS
1-AMINO-3,4-DICHLOROBENZENE95-76-1BKH
1-BUTYLPROPANE104-51-8JNIHS
1-CHLORO-2-NITROBENZENE88-73-3RTECS
1-EPOXYETHYL-3,4-EPIXYCYCLOHEXANE106-87-6RTECS
1-ETHYL-4-HYDROXYBENZENE123-07-9JNIHS
1-HYDROXY-4-SEC-BUTYLBENZENE99-71-8JNIHS
1-HYDROXY-4-TERT-BUTYLBENZENE98-54-4JNIHS
1-METHYL-4-NITROBENZENE99-99-0JNIHS
2,2',4,4',5,5'-HEXACHLOROBIPHENYL (PCB-153)35065-27-1BKH
2,2',4,4'-TETRACHLOROBIPHENYL (PCB-47)2437-79-8BKH
2,2',6,6'-TETRABROMO-4,4'-ISOPROPYLIDENEDIPHENOL79-94-7JNIHS
2,3,3',4,4',5'-HEXACHLOROBIPHENYL69782-90-7WWF
2,3,3',4,4'-PENTACHLOROBIPHENYL (PCB-105)32598-14-4WWF
2,3,4,4',5- PENTACHLOROBIPHENYL EDF-505WWF
2,3,4,7,8-PENTACHLORODIBENZOFURAN57117-31-4BKH, WWF
2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN (TCDD)1746-01-6BKH, BRUC, IL-EPA, JNIHS, KEIT, OEHHA-CREL, RTECS, WWF
2,3,7,8-TETRACHLORODIBENZOFURAN51207-31-9IL-EPA, JNIHS, RTECS, WWF
2,4,5-T93-76-5IL-EPA, JNIHS, KEIT
2,4-D94-75-7IL-EPA, JNIHS, KEIT
2,4-DIAMINOANISOLE SULFATE39156-41-7RTECS
2,4-DICHLOROPHENOL120-83-2JNIHS, KEIT
2,6-DIMETHYL-4-HEPTYLPHENOL, (O AND P)25154-52-3JNIHS, WWF
2-(2-(2-(2-(NONYLPHENOXY)ETHOXY)ETHOXY)ETHOXY)ETHANOL9016-45-9JNIHS
2-BROMOPROPANE75-26-3JNIHS
2-CHLOR-1,3-BUTADIENE126-99-8RTECS
2-METHYLLACTONITRILE75-86-5NJ-FS
2-PROPENOIC ACID, 2-METHYL-, METHYL ESTER = STANNANE, TRIBUTYLMEACRYLATE26354-18-7BKH
3'-METHYL-4-DIMETHYLAMINOAZOBENZENE55-80-1RTECS
3,3',4,4'-TETRACHLOROBIPHENYL (PCB-77)32598-13-3BKH, RTECS, WWF
3,3'4,4',5,5'-HEXACHLOROBIPHENYL (PCB-169)32774-16-6BKH, WWF
3-METHYLCHLORANTHRENE56-49-5BRUC
3-TERT-BUTYLPHENOL585-34-2JNIHS
4,4'-DIAMINODIPHENYL ETHER101-80-4RTECS
4,4'-DIAMINODIPHENYL SULFIDE139-65-1RTECS
4,4'-ISOPROPYLIDENEDIPHENOL80-05-7BKH, GUIL, IL-EPA, JNIHS, KEIT, RTECS, WWF
4,4'-METHYLENEBIS-DIHYDROCHLORIDE BENZENEMINE13552-44-8RTECS
4-(1,1,3,3-TETRAMETHYLBUTYL)PHENOL140-66-9JNIHS
4-AMINO-BENZOLSULFONYL-METHYLCARBAMAT3337-71-1RTECS
4-DODECYLPHENOL104-43-8JNIHS
4-N-PROPYLPHENOL645-56-7JNIHS
4-NONYLPHENOL104-40-5IL-EPA, JNIHS
4-NONYLPHENOL BRANCHED84852-15-3JNIHS
ACETOCHLOR34256-82-1BKH, WWF
ALACHLOR15972-60-8BKH, IL-EPA, JNIHS, KEIT, WWF
ALDICARB116-06-3GUIL, JNIHS, KEIT
ALDRIN309-00-2IL-EPA, JNIHS
ALKYLPHENOLSEDF-149GUIL
ALPHA-ENDOSULFAN959-98-8IL-EPA
ALPHA-OXODIPHENYLMETHANE119-61-9JNIHS, WWF
AMIODARONE1951-25-3RTECS
AMIODARONE HYDROCHLORIDE19774-82-4RTECS
AMITROLE61-82-5BRUC, EPA-SDWA, IL-EPA, JNIHS, KEIT, RTECS, WWF
AMOXAPINE14028-44-5RTECS
ANILINE, M-CHLORO-, HYDROCHLORIDE141-85-5RTECS
ANTHRACENE120-12-7KEIT
AROCLOR 124253469-21-9BKH
AROCLOR 124812672-29-6BKH
AROCLOR 125411097-69-1BKH
AROCLOR 126011096-82-5BKH
ARSENIC7440-38-2KEIT, WWF
ARSINE7784-42-1RTECS
ATRAZINE1912-24-9BKH, GUIL, IL-EPA, JNIHS, KEIT, WWF
AZADIRACHTIN11141-17-6JNIHS
BENOMYL17804-35-2EPA-SDWA, IL-EPA, JNIHS, KEIT
BENZENE71-43-2RTECS
BENZENECARBOPEROXOIC ACID, 1,1-DIMETHYLETHYL ESTER614-45-9RTECS
BENZETHONIUM CHLORIDE121-54-0RTECS
BENZO(A)PYRENE50-32-8KEIT, WWF
BENZYL BUTYL PHTHALATE85-68-7BKH, JNIHS, KEIT, WWF
BETA-ENDOSULFAN33213-65-9IL-EPA
BETA-LINDANE319-85-7IL-EPA, JNIHS, KEIT
BIS(2-ETHYLHEXYL) ADIPATE103-23-1JNIHS
BIS(2-ETHYLHEXYL)PHTHALATE117-81-7BKH, BRUC, IL-EPA, JNIHS, KEIT, WWF
BIS(TRIBUTYLTIN) OXIDE56-35-9BKH, EPA-SDWA, RTECS
BISPHENOL F2467-02-9JNIHS, WWF
BORATES,TETRA,SODIUM SALTS1303-96-4RTECS
BROMACIL314-40-9EPA-TRI
BROMACIL LITHIUM SALT (2,4(H,3H)-PYRIMIDINEDIONE, ETHYL-3 (1-METHYLPROPYL), LITHIUM SALT)53404-19-6EPA-TRI
BROMINE7726-95-6EPA-TRI
BUTYLATED HYDROXYANISOLE (BHA)25013-16-5JNIHS, WWF
C.I. BASIC RED 9 MONOHYDROCHLORIDE569-61-9RTECS
C.I. DIRECT BLUE 21828407-37-6RTECS
CADMIUM7440-43-9IL-EPA, KEIT, WWF
CADMIUM CHLORIDE10108-64-2RTECS
CAMPHECHLOR8001-35-2BKH, GUIL, IL-EPA, JNIHS, KEIT, WWF
CARBARYL63-25-2JNIHS, KEIT, WWF
CARBENDAZIM10605-21-7JNIHS, WWF
CARBON DISULFIDE75-15-0BRUC, RTECS
CARBON TETRACHLORIDE56-23-5RTECS
CHLORDANE57-74-9BKH, IL-EPA, JNIHS, WWF
CHLORDECONE (KEPONE)143-50-0BKH, EPA-SDWA, IL-EPA, JNIHS, WWF
CHLORINATED DIPHENYL OXIDE55720-99-5BRUC
CHLORINATED PARAFINS (AVERAGE CHAIN LENGTH, C12; APPROXIMATELY 60 PERCENT CHLORINE BY WEIGHT)108171-26-2RTECS
CHLORMEQUAT CHLORIDE999-81-5RTECS
CHLORODIFLUOROMETHANE75-45-6OEHHA-CREL
CHLOROFORM67-66-3RTECS, WWF
CHLORPYRIFOS2921-88-2KEIT
CIS-CHLORDANE5103-71-9IL-EPA
CLOFENTEZINE74115-24-5JNIHS, WWF
COBALT CHLORIDE7646-79-9RTECS
COBALT SULFATE HEPTAHYDRATE10026-24-1RTECS
COPPER (11)-8-HYDROXYQUINOLINE10380-28-6RTECS
CYANIDE COMPOUNDS1073EPA-HEN
CYCLOSPORIN A59865-13-3RTECS
CYPERMETHRIN52315-07-8JNIHS, KEIT, WWF
D-TRANS-ALLETHRIN28057-48-9WWF
DDD72-54-8BRUC, IL-EPA, JNIHS, KEIT
DDE72-55-9BRUC, GUIL, IL-EPA, JNIHS, KEIT, WWF
DDT50-29-3BKH, BRUC, IL-EPA, JNIHS, KEIT, RTECS, WWF
DECAHYDRONAPTHALENE91-17-8RTECS
DEMECLOCYCLINE127-33-3RTECS
DI-N-HEXYLPHTHALATE84-75-3BRUC, JNIHS
DI-N-OCTYL PHTHALATE117-84-0BRUC, JNIHS
DI-N-PENTYL PHTHALATE131-18-0JNIHS
DI-OH-BENZOICACIDS (DHBA)EDF-374BRUC
DIBENZOFURANS (CHLORINATED)1080BRUC, OEHHA-CREL, WWF
DIBROMOACETIC ACID631-64-1JNIHS
DIBUTYL PHTHALATE84-74-2BKH, JNIHS, KEIT, WWF
DICHLOROMETHANE75-09-2RTECS
DICOFOL115-32-2EPA-SDWA, IL-EPA, JNIHS, KEIT, WWF
DICYCLOPENTADIENYL IRON102-54-5RTECS
DIELDRIN60-57-1GUIL, IL-EPA, JNIHS, KEIT, WWF
DIETHYL PHTHALATE84-66-2JNIHS, WWF
DIETHYLENE GLYCOL MONOMETHYL ETHER111-77-3RTECS
DIETHYLSTILBESTROL56-53-1IL-EPA
DIFLUBENZURON35367-38-5JNIHS, RTECS
DIMETHOATE60-51-5BRUC
DINITROBUTYL PHENOL88-85-7JNIHS
DINITROPHENOLS25550-58-7BRUC
DINOCAP39300-45-3RTECS
DIPHENYLHYDANTOIN (PHENYTOIN), SODIUM SALT630-93-3RTECS
DIPROPYL PHTHALATE131-16-8JNIHS
ENDOSULFAN115-29-7GUIL, IL-EPA, JNIHS, KEIT, WWF
ENDRIN72-20-8IL-EPA, JNIHS
EPICHLOROHYDRIN106-89-8RTECS
ESFENVALERATE66230-04-4EPA-SDWA, JNIHS
ETHANE DIMETHANE SULPHONATEEDF-503WWF
ETHANOL64-17-5RTECS
ETHIOZIN (EBUZIN/TYCOR)64529-56-2JNIHS
ETHYLBENZENE100-41-4OEHHA-CREL
ETHYLENE GLYCOL MONOBUTYL ETHER111-76-2RTECS
ETHYLENE GLYCOL MONOETHYL ETHER110-80-5RTECS
ETHYLENE GLYCOL MONOMETHYL ETHER109-86-4RTECS
ETHYLENE THIOUREA96-45-7BRUC, JNIHS, OEHHA-CREL, RTECS, WWF
ETOPOSIDE33419-42-0RTECS
FENARIMOL60168-88-9WWF
FENBUCONAZOLE (FENETHANIL)114369-43-6WWF
FENITROTHION122-14-5WWF
FENOXYCARB72490-01-8JNIHS, RTECS
FENVALERATE51630-58-1EPA-SDWA, JNIHS, WWF
FERBAM14484-64-1BRUC
FIPRONIL120068-37-3WWF
FIREMASTER FF-167774-32-7JNIHS, WWF
GAMMA-LINDANE58-89-9BKH, JNIHS, KEIT, WWF
HC BLUE 12784-94-3RTECS
HEPTACHLOR76-44-8IL-EPA, JNIHS, KEIT, WWF
HEPTACHLOR EPOXIDE1024-57-3IL-EPA, JNIHS, KEIT, WWF
HEXACHLORO-1,3-BUTADIENE87-68-3RTECS
HEXACHLOROBENZENE118-74-1BKH, BRUC, IL-EPA, JNIHS, KEIT, RTECS
HEXACONAZOLE (ANVIL)79983-71-4JNIHS
HYDRAZINE302-01-2OEHHA-CREL, RTECS
HYDROGEN CYANIDE74-90-8EPA-HEN, OEHHA-CREL
IODINATED GLYCEROL5634-39-9RTECS
IODINE7553-56-2ATSDR, RTECS
IODINE-13110043-66-0BRUC
IOXYNIL1689-83-4BRUC
IPRODIONE36734-19-7JNIHS, WWF
KEROSENE8008-20-6RTECS
KETOCONAZOLE65277-42-1RTECS, WWF
LEAD7439-92-1BRUC, IL-EPA, KEIT, WWF
LINURON330-55-2BKH, WWF
LITHIUM CARBONATE554-13-2RTECS
LORAZEPAM846-49-1RTECS
MALATHION121-75-5BRUC, JNIHS, KEIT, WWF
MANCOZEB8018-01-7BRUC, EPA-SDWA, IL-EPA, JNIHS, KEIT, WWF
MANEB12427-38-2BKH, BRUC, IL-EPA, JNIHS, KEIT, WWF
MERCURY7439-97-6IL-EPA, KEIT, WWF
MERCURY CHLORIDE (2)7487-94-7RTECS
METHAM SODIUM137-42-8BKH
METHIMAZOLE60-56-0RTECS
METHOMYL16752-77-5JNIHS, KEIT, WWF
METHOXYCHLOR72-43-5IL-EPA, JNIHS, KEIT, WWF
METHOXYETYLACRYLATE TINBUTYLTIN, COPOLYMEREDF-501BKH
METHYL PARATHION298-00-0IL-EPA, JNIHS
METHYLTHIOURACIL56-04-2RTECS
METIRAM9006-42-2EPA-SDWA, IL-EPA, JNIHS, KEIT
METRIBUZIN21087-64-9JNIHS, KEIT, WWF
MIREX2385-85-5BKH, EPA-SDWA, IL-EPA, JNIHS, KEIT, RTECS, WWF
MOLINATE2212-67-1JNIHS
MONO-2-ETHYLHEXYL PHTHALATE4376-20-9JNIHS
MONOCHLOROBIPHENYL27323-18-8JNIHS
N,N-DIMETHYLANILINE121-69-7RTECS
NABAM142-59-6BRUC, RTECS
NALIDIXIC ACID389-08-2RTECS
NICKEL SULFATE7786-81-4RTECS
NIFEDIPINE21829-25-4RTECS
NITROFEN1836-75-5EPA-SDWA, JNIHS, KEIT, WWF
NITROGEN DIOXIDE10102-44-0RTECS
NONACHLOR, CIS-5103-73-1IL-EPA
NONACHLOR, TRANS-39765-80-5EPA-SDWA, IL-EPA, JNIHS, WWF
NORETHISTERONE68-22-4RTECS
NORFLURAZON27314-13-2EPA-TRI
O,P'-DDT789-02-6GUIL
O-CRESOL95-48-7RTECS
OCTACHLOROSTYRENEEDF-151EPA-SDWA, JNIHS, WWF
OCTYLPHENOXY POLYETHOXYETHANOL9036-19-5JNIHS
OCTYLPHENOXYPOLYETHOXYETHANOL9002-93-1JNIHS
ORYZALIN19044-88-3JNIHS
OXAZEPAM604-75-1RTECS
OXYCHLORDANE27304-13-8EPA-SDWA, IL-EPA, JNIHS, WWF
OXYDEMETON METHYL301-12-2JNIHS
OXYPHENBUTAZONE129-20-4RTECS
P-CHLOROANILINE.HCL20265-96-7RTECS
P-CHLOROPHENYL ISOCYANATE104-12-1RTECS
P-TERT-AMYLPHENOL80-46-6JNIHS
PARATHION56-38-2EPA-SDWA, IL-EPA, JNIHS, KEIT
PCB, HYDROXYLATEDEDF-507WWF
PENDIMETHALIN40487-42-1JNIHS, WWF
PENTA- TO NONYL-PHENOLSEDF-194EPA-SDWA
PENTACHLOROANISOLE1825-21-4RTECS
PENTACHLOROPHENOL87-86-5ATSDR, BRUC, IL-EPA, JNIHS, KEIT, RTECS, WWF
PENTAMIDINE140-64-7RTECS
PERFLUOROOCTANE SULFONATE (PFOS)EDF-508WWF
PERMETHRIN52645-53-1EPA-SDWA, JNIHS, WWF
PHENOL, 2-[[(TRIBUTYLSTANNYL)OXY]CARBONY4342-30-7BKH
PHENOTHRIN26002-80-2JNIHS, WWF
PHTHALATESEDF-150GUIL
PICLORAM1918-02-1RTECS
POLYBROMINATED BIPHENYLSPJL335ATSDR, BKH, BRUC, EPA-SDWA, IL-EPA, WWF
POLYCHLORINATED BIPHENYLS1336-36-3BKH, BRUC, GUIL, IL-EPA, JNIHS, KEIT, WWF
POLYCHLORINATED DIBENZO-P-DIOXINSPCDDWWF
PROCARBAZINE HYDROCHLORIDE366-70-1RTECS
PROCYMIDONE32809-16-8JNIHS, WWF
PRODIAMINE (RYDEX)29091-21-2WWF
PRONAMIDE23950-58-5JNIHS
PROPANIL709-98-8RTECS
PROPYLTHIOURACIL51-52-5RTECS
PYRIMETHANIL53112-28-0WWF
PYRIMINIL53558-25-1RTECS
QUARTZ14808-60-7RTECS
QUINTOZENE82-68-8WWF
RESORCINOL108-46-3BKH, BRUC, WWF
SIMAZINE122-34-9JNIHS
STANNANE, ACETOXYTRIPHENYL900-95-8BKH
STANNANE, TRIBUTYL = TRIBUTYLTIN NAPHTALATE36631-23-9BKH
STANNANE, TRIBUTYL-, MONO(NAPHTHENOYLOXY85409-17-2BKH
STANNANE, TRIBUTYL[(1-OXO-9,12-OCTADECAD24124-25-2BKH
STANNANE, TRIBUTYL[(1-OXO-9-OCTADECENYL)3090-35-5BKH
STANNANE, TRIBUTYL[[[1,2,3,4,4A,4B,5,6,126239-64-5BKH
STANNANE, [1,2-PHENYLENEBIS(CARBONYLOXY)4782-29-0BKH
STRONTIUM (STABLE STRONTIUM CHLORIDE)10476-85-4RTECS
STYRENE100-42-5BKH, IL-EPA, JNIHS, KEIT, WWF
SULFAMETHAZINE57-68-1RTECS
SULFAMETHOXAZOLE723-46-6RTECS
SYNTHETIC PYRETHROIDSEDF-152EPA-SDWA, JNIHS
T-2 TOXIN21259-20-1RTECS
TARSTAREDF-506WWF
TEFLUTHRIN79538-32-2WWF
TETRACHLORO DDT = 1,1,1,2-TETRACHLORO-2,2-BIS(4-CHLOROPHENYL)ETHANE3563-45-9BKH
TETRAHYDROFURAN109-99-9RTECS
TETRASUL2227-13-6RTECS
THEOBROMINE83-67-0RTECS
THEOPHYLLINE58-55-9RTECS
THIAZOPYR (MON 13200)117718-60-2WWF
THIOCYANATEEDF-058BRUC
THIOPHANATE ETHYL23564-06-9EPA-TRI
THIOPHENE110-02-1RTECS
THIRAM137-26-8BKH, WWF
TOLBUTAMIDE64-77-7RTECS
TRANS-CHLORDANE5103-74-2KEIT
TRI-N-PROPYLTIN (TPRT)2279-76-7BKH
TRIADIMEFON43121-43-3WWF
TRIADIMENOL (BAYTAN)55219-65-3WWF
TRIBUTYLTIN688-73-3BKH, IL-EPA, WWF
TRIBUTYLTIN BENZOATE4342-36-3BKH
TRIBUTYLTIN COMPOUNDSEDF-184BKH
TRIBUTYLTIN FLUORIDE1983-10-4BKH
TRIBUTYLTIN METHACRYLATE2155-70-6BKH
TRIBUTYLTINCARBOXYLATEEDF-499BKH
TRIBUTYLTINNAPHTHALATE26636-32-8BKH
TRIBUTYLTINPOLYETHOXYLATEEDF-500BKH
TRICHLOROETHYLENE79-01-6EPA-HEN
TRIFLURALIN1582-09-8IL-EPA, JNIHS, KEIT, WWF
TRIPHENYLTIN668-34-8BKH
UREA, N,N-DIMETHYL-N'-(3-CHLORO-4-METHOXYPHENYL)-19937-59-8RTECS
VINCLOZOLIN50471-44-8BKH, EPA-SDWA, EPA-TRI, GUIL, IL-EPA, JNIHS, KEIT, WWF
VM & P (VARISH MAKERS & PAINTERS) NAPHTHA8030-30-6RTECS
ZINEB12122-67-7BKH, BRUC, EPA-SDWA, IL-EPA, JNIHS, KEIT, RTECS, WWF
ZIRAM137-30-4EPA-SDWA, JNIHS, KEIT, WWF

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