Organophosphate pesticides account for about half of the insecticides used in the United States. A large number of organophosphate pesticides metabolize to dialkyl phosphate metabolites and other specific metabolites. There are six dialkyl phosphate metabolites; each of these can be produced from the metabolism of more than one organophosphate pesticide.
Organophosphate pesticides act by interfering with the transmission of signals in the nervous systems of both insects and humans, if humans are exposed in high enough amounts. Organophosphate pesticides injure and even kill large numbers of people around the world every year, and have been associated with chronic nervous system damage in people who survive poisoning.
Scorecard provides information on the health hazards of organophosphate pesticides as a category in the link below and for four of the six dialkyl metabolites. For more information on the health hazards of dialkyl metabolites and the parent organophosphate pesticides that they come from follow the appropriate links below. CDC's biomonitoring results for metabolites are available at http://www.cdc.gov/exposurereport/pesticides/organophosphate_dpm/default.htm